Back to Search Start Over

Syntheses of Acyclic and Macrocyclic Compounds Derived from 9,9‐Diethylfluorene (Part I)

Syntheses of Acyclic and Macrocyclic Compounds Derived from 9,9‐Diethylfluorene (Part I)

Authors :
Seidel, Pierre
Mazik, Monika
Technische Universität Bergakademie Freiberg
Source :
ChemistryOpen
Publication Year :
2020
Publisher :
John Wiley and Sons Inc., 2020.

Abstract

A series of new 9,9‐diethylfluorenes consisting of three side‐arms each bearing a heterocyclic, bis(carboxymethyl)amino, bis(carbamoylmethyl)amino, bis(ethoxycarbonylmethyl)amino or an amino group were prepared on the basis of 2,4,7‐tris(bromomethyl)‐9,9‐diethylfluorene. Imidazolyl, benzimidazolyl, pyrazolyl, pyrrolyl, 1,3‐dioxoisoindolyl and pyridinium groups were taken into account as heterocyclic units, attached to the aromatic skeleton via −CH2−, −CH2NHCH2− or −CH2N=CH− linkers. In addition to the seventeen 2,4,7‐trisubstituted 9,9‐diethylfluorenes, two macrocyclic compounds were prepared on the basis of 2,7‐bis(aminomethyl)‐9,9‐diethylfluorene. The excellent yield of the macrocyclization reaction is worth a special mention. Both the acyclic and the macrocyclic fluorene‐based compounds have, among other things, the potential to act as artificial receptors for different substrates in analogy to the known receptors consisting of a benzene or biphenyl core.<br />The syntheses of a series of new 2,4,7‐trisubstituted 9,9‐diethylfluorenes (seventeen compounds) as well as of fluorene‐derived macrocycles (two compounds) are the topics of this work. The knowledge gained from this study is very useful for the synthesis of numerous fluorene derivatives displaying different substitution pattern.

Details

Language :
English
ISSN :
21911363
Volume :
9
Issue :
11
Database :
OpenAIRE
Journal :
ChemistryOpen
Accession number :
edsair.pmid.dedup....83d69f94e0684ae6a0c1cdb6fec00ffd