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Syntheses of Acyclic and Macrocyclic Compounds Derived from 9,9‐Diethylfluorene (Part I)
Syntheses of Acyclic and Macrocyclic Compounds Derived from 9,9‐Diethylfluorene (Part I)
- Source :
- ChemistryOpen
- Publication Year :
- 2020
- Publisher :
- John Wiley and Sons Inc., 2020.
-
Abstract
- A series of new 9,9‐diethylfluorenes consisting of three side‐arms each bearing a heterocyclic, bis(carboxymethyl)amino, bis(carbamoylmethyl)amino, bis(ethoxycarbonylmethyl)amino or an amino group were prepared on the basis of 2,4,7‐tris(bromomethyl)‐9,9‐diethylfluorene. Imidazolyl, benzimidazolyl, pyrazolyl, pyrrolyl, 1,3‐dioxoisoindolyl and pyridinium groups were taken into account as heterocyclic units, attached to the aromatic skeleton via −CH2−, −CH2NHCH2− or −CH2N=CH− linkers. In addition to the seventeen 2,4,7‐trisubstituted 9,9‐diethylfluorenes, two macrocyclic compounds were prepared on the basis of 2,7‐bis(aminomethyl)‐9,9‐diethylfluorene. The excellent yield of the macrocyclization reaction is worth a special mention. Both the acyclic and the macrocyclic fluorene‐based compounds have, among other things, the potential to act as artificial receptors for different substrates in analogy to the known receptors consisting of a benzene or biphenyl core.<br />The syntheses of a series of new 2,4,7‐trisubstituted 9,9‐diethylfluorenes (seventeen compounds) as well as of fluorene‐derived macrocycles (two compounds) are the topics of this work. The knowledge gained from this study is very useful for the synthesis of numerous fluorene derivatives displaying different substitution pattern.
- Subjects :
- Makrocyclische Verbindungen
heterocycles
Full Paper
macrocyclization
Fluren
fluorenophane
Publikationsfonds
Heterocyclische Verbindungen
publishing fund, artificial receptors, fluorenophane, heterocycles, imines, macrocyclization
Full Papers
Organische Synthese
Flurenderivate
imines
ddc:540
artificial receptors
Subjects
Details
- Language :
- English
- ISSN :
- 21911363
- Volume :
- 9
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- ChemistryOpen
- Accession number :
- edsair.pmid.dedup....83d69f94e0684ae6a0c1cdb6fec00ffd