[Association of cerebral stroke with a phosphodiesterase 4D (PDE4D) gene polymorphism in the Moscow population]

We studied SNP41 (rs152312) and SNP87 (rs2910829) of the PDE4D gene in 577 stroke patients and 270 healthy controls. The significant differences in the distribution of genotype and allele frequencies of the SNP41 between patients and controls were revealed. Genotypes AA and AG were associated with the higher risk of stroke in the Moscow population (OR 1,6). No association between SNP87 and stroke was found.