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New Acetophenones and Chromenes from the Leaves of Melicope barbigera A. Gray
- Source :
- Molecules, Vol 26, Iss 688, p 688 (2021), Molecules, Volume 26, Issue 3
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The dichloromethane extract from leaves of Melicope barbigera (Rutaceae), endemic to the Hawaiian island of Kaua’i, yielded four new and three previously known acetophenones and 2H-chromenes, all found for the first time in M. barbigera. The structures of the new compounds obtained from the dichloromethane extract after purification by chromatographic methods were unambiguously elucidated by spectroscopic analyses including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration was determined by modified Mosher’s method. Compounds 2, 4 and the mixture of 6 and 7 exhibited moderate cytotoxic activities against the human ovarian cancer cell line A2780 with IC50 values of 30.0 and 75.7 µM for 2 and 4, respectively, in a nuclear shrinkage cytotoxicity assay.
- Subjects :
- Ovarian Neoplasms
Methylene Chloride
Magnetic Resonance Spectroscopy
melibarbichromen A and B
Melicope barbigera
Article
Hawaii
acetophenones
Plant Leaves
lcsh:QD241-441
lcsh:Organic chemistry
Cell Line, Tumor
ovarian cancer cell line A2780
melibarbinon A and B
cytotoxicity
Humans
Benzopyrans
Female
Rutaceae
chromenes
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 688
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.pmid.dedup....7f2f8b697adc3f850c09086f9bc77dd7