Back to Search
Start Over
The utility of serology for elimination surveillance of trachoma
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018), Nature communications, vol 9, iss 1, Nature Communications, Nat Commun
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Robust surveillance methods are needed for trachoma control and recrudescence monitoring, but existing methods have limitations. Here, we analyse data from nine trachoma-endemic populations and provide operational thresholds for interpretation of serological data in low-transmission and post-elimination settings. Analyses with sero-catalytic and antibody acquisition models provide insights into transmission history within each population. To accurately estimate sero-conversion rates (SCR) for trachoma in populations with high-seroprevalence in adults, the model accounts for secondary exposure to Chlamydia trachomatis due to urogenital infection. We estimate the population half-life of sero-reversion for anti-Pgp3 antibodies to be 26 (95% credible interval (CrI): 21–34) years. We show SCRs below 0.015 (95% confidence interval (CI): 0.0–0.049) per year correspond to a prevalence of trachomatous inflammation—follicular below 5%, the current threshold for elimination of active trachoma as a public health problem. As global trachoma prevalence declines, we may need cross-sectional serological survey data to inform programmatic decisions.<br />Robust surveillance methods are needed for trachoma control and recrudescence monitoring, but existing methods have limitations. Here, Pinsent et al. analyse data from nine trachoma-endemic populations and provide operational thresholds for interpretation of serological data in low transmission and post-elimination settings.
- Subjects :
- Adult
Adolescent
Science
Chlamydia trachomatis
Pacific Islands
Article
Young Adult
Nepal
Models
Seroepidemiologic Studies
Humans
Public Health Surveillance
Child
Preschool
lcsh:Science
Africa South of the Sahara
Trachoma
Models, Statistical
Age Factors
Infant
Statistical
eye diseases
Good Health and Well Being
Child, Preschool
Female
lcsh:Q
Infection
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.pmid.dedup....7f0926c2a1b9b41eed9b92b0284dfb6c