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The aptamer BT200 blocks von Willebrand factor and platelet function in blood of stroke patients
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- The effect of conventional anti-platelet agents is limited in secondary stroke prevention, and their effects are blunted under high shear stress in the presence of increased levels of circulating von Willebrand factor (VWF). VWF is critically involved in thrombus formation at sites of stenotic extracranial/intracranial arteries. A third generation anti-VWF aptamer (BT200) has been generated which could be useful for secondary stroke prevention. To characterize the effects of BT200 in blood of patients with large artery atherosclerosis stroke (LAA). Blood samples were obtained from 33 patients with acute stroke or transient ischemic attack to measure inhibition of VWF activity and VWF-dependent platelet function. Patients who received clopidogrel or dual antiplatelet therapy did not differ in VWF dependent platelet function tests from aspirin treated patients. Of 18 patients receiving clopidogrel with or without aspirin, only 3 had a prolonged collagen adenosine diphosphate closure time, and none of the patients had ristocetin induced aggregation in the target range. BT200 concentration-dependently reduced median VWF activity from 178 to 300 s. Baseline VWF activity correlated (r = 0.86, p
- Subjects :
- Blood Platelets
Male
Cerebrovascular disorders
Aspirin
Platelet Aggregation
Science
Thrombosis
Intracranial Arteriosclerosis
Article
Stroke
Ischemic Attack, Transient
hemic and lymphatic diseases
von Willebrand Factor
Humans
Medicine
Female
Collagen
Aptamers, Peptide
Aged
circulatory and respiratory physiology
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.pmid.dedup....7d9eb8ca94cec5383109df8db5371151