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Efficacy of topical and systemic itraconazole as a broad-spectrum antifungal agent in mycotic corneal ulcer. A preliminary study
- Source :
- Indian Journal of Ophthalmology, Vol 49, Iss 3, Pp 173-176 (2001)
- Publication Year :
- 2005
-
Abstract
- Purpose: To evaluate the efficacy of topical (1%) and systemic itraconazole against common fungi such as Aspergillus and other filamentous fungi that cause mycotic corneal ulcer. Methods: A prospective randomised, controlled study was done in 54 clinically suspected cases of fungal keratitis of which 44 were culture proven. Half the cases (n=27) with superficial involvement were treated with only topical itraconazole (1%) and the other half were treated with both topical and systemic itraconazole. Results:Aspergillus, Penicillium and Fusarium were the most common fungi isolated. The ulcer resolved in 42 eyes (77%) and 12 eyes (23%) did not respond well to treatment. Four of 12 non-responding eyes were caused by Fusarium species. Conclusion: Itraconazole, given either topically or systemically, is effective in treating mycotic corneal ulcers.
- Subjects :
- Adult
Male
Antifungal Agents
Cross-Over Studies
fluconazole
Administration, Topical
Mycotic keratitis
Penicillium
Administration, Oral
Middle Aged
natamycin
Aspergillus
Treatment Outcome
lcsh:Ophthalmology
Fusarium
Mycoses
lcsh:RE1-994
Humans
Female
Prospective Studies
Itraconazole
Corneal Ulcer
Eye Infections, Fungal
Subjects
Details
- ISSN :
- 03014738
- Volume :
- 49
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Indian journal of ophthalmology
- Accession number :
- edsair.pmid.dedup....73dcad728a2648675c473dfd25f843cd