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SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection
- Source :
- PLoS ONE, Vol 17, Iss 1, p e0262169 (2022), PLoS ONE, PLoS ONE, Vol 17, Iss 1 (2022)
- Publication Year :
- 2022
- Publisher :
- Public Library of Science (PLoS), 2022.
-
Abstract
- Current SARS-CoV-2 serological assays generate discrepant results, and the longitudinal characteristics of antibodies targeting various antigens after asymptomatic to mild COVID-19 are yet to be established. This longitudinal cohort study including 1965 healthcare workers, of which 381 participants exhibited antibodies against the SARS-CoV-2 spike antigen at study inclusion, reveal that these antibodies remain detectable in most participants, 96%, at least four months post infection, despite having had no or mild symptoms. Virus neutralization capacity was confirmed by microneutralization assay in 91% of study participants at least four months post infection. Contrary to antibodies targeting the spike protein, antibodies against the nucleocapsid protein were only detected in 80% of previously anti-nucleocapsid IgG positive healthcare workers. Both anti-spike and anti-nucleocapsid IgG levels were significantly higher in previously hospitalized COVID-19 patients four months post infection than in healthcare workers four months post infection (p = 2*10(-23) and 2*10(-13) respectively). Although the magnitude of humoral response was associated with disease severity, our findings support a durable and functional humoral response after SARS-CoV-2 infection even after no or mild symptoms. We further demonstrate differences in antibody kinetics depending on the antigen, arguing against the use of the nucleocapsid protein as target antigen in population-based SARS-CoV-2 serological surveys.
- Subjects :
- RNA viruses
Male
Viral Diseases
Pulmonology
Coronaviruses
Physiology
Infektionsmedicin
Antibodies, Viral
Biochemistry
Nucleocapsids
Severity of Illness Index
Medical Conditions
Immune Physiology
Medicine and Health Sciences
Longitudinal Studies
Enzyme-Linked Immunoassays
Asymptomatic Infections
Pathology and laboratory medicine
Immune System Proteins
Medical microbiology
Middle Aged
Infectious Diseases
Serology
Viruses
Spike Glycoprotein, Coronavirus
Medicine
Female
SARS CoV 2
Pathogens
Research Article
Adult
Infectious Medicine
SARS coronavirus
Health Personnel
Science
Immunology
Viral Structure
Research and Analysis Methods
Microbiology
Antibodies
Respiratory Disorders
Virology
Humans
Immunoassays
Nucleocapsid
Biology and life sciences
SARS-CoV-2
Organisms
Viral pathogens
Immunity
Proteins
COVID-19
Covid 19
Antibodies, Neutralizing
Microbial pathogens
Immunity, Humoral
Immunoglobulin G
Respiratory Infections
Humoral Immunity
Immunologic Techniques
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.pmid.dedup....63abe05e9052f5e92742561faea4c172