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Genetic variation in FTO and mortality
- Source :
- Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Obesity Reviews, 16(4), 327-340. Wiley-Blackwell Publishing Ltd, Obesity Reviews, 16(4), 327-340, Obesity Reviews, vol. 16, no. 4, pp. 327-340
- Publication Year :
- 2015
-
Abstract
- Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, we conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. Linear regression showed that the minor allele of the FTO SNP was associated with greater BMI (n = 169,551; 0.32 kg m(-2) ; 95% CI 0.28-0.32, P
- Subjects :
- obesity
nutritional and metabolic diseases
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Genetic Variation
Proteins
mortality
Polymorphism, Single Nucleotide
Article
Body Mass Index
meta-analysis
Observational Studies as Topic
Humans
Genetic Predisposition to Disease
Waist Circumference
FTO
Adiposity
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 14677881
- Database :
- OpenAIRE
- Journal :
- Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Obesity Reviews, 16(4), 327-340. Wiley-Blackwell Publishing Ltd, Obesity Reviews, 16(4), 327-340, Obesity Reviews, vol. 16, no. 4, pp. 327-340
- Accession number :
- edsair.pmid.dedup....5ff0e22b0986589e135928ab742db1bb