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Energy Expenditure in Older People Hospitalized for an Acute Episode

Authors :
Bonnefoy, M.
Gilbert, T.
Normand, S.
Jauffret, M.
Roy, P.
Morio, B.
Cornu, C.
Roche, S.
Laville, M.
Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN)
Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon)
Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon-Institut National de la Recherche Agronomique (INRA)
Service de médecine gériatrique, centre hospitalier Lyon Sud
Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS)
Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)
Direction des Applications Militaires (DAM)
Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Synchrotron SOLEIL (SSOLEIL)
Centre National de la Recherche Scientifique (CNRS)
Motricité, interactions, performance EA 4334 / Movement - Interactions - Performance (MIP)
Le Mans Université (UM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS)
Université de Nantes (UN)-Université de Nantes (UN)
Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Barcelona Institute of Science and Technology (BIST)
Institució Catalana de Recerca i Estudis Avançats (ICREA)
Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon)
Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Service de Biostatistiques [Lyon]
Hospices Civils de Lyon (HCL)
INRAE Transfert
CarMeN, laboratoire
Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL)
Laboratoire Motricité, Interactions, Performance
Université de Nantes (UN)
Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Barcelona Institute of Science and Technology (BIST)
Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS)
Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Le Mans Université (UM)
Source :
Nutrients, Nutrients, 2019, 11 (12), ⟨10.3390/nu11122946⟩, Nutrients, MDPI, 2019, 11 (12), pp.2946. ⟨10.3390/nu11122946⟩, Volume 11, Issue 12
Publication Year :
2019
Publisher :
HAL CCSD, 2019.

Abstract

Weight loss and worsening of nutritional state is a frequent downfall of acute hospitalization in older people. It is usually accepted that acute inflammation is responsible for hypercatabolism. However, several studies suggest, on the contrary, a reduction in resting energy expenditure (REE). This study aimed to obtain a reliable measure of REE and total energy expenditure (TEE) in older patients hospitalized for an acute episode in order to better assess patients&rsquo<br />energy requirements and help understand the mechanisms of weight loss in this situation. Nineteen hospitalized older patients (mean age 83 years) with C-reactive protein (CRP) level &gt<br />20mg/L were recruited. REE and TEE were measured using gold standard methods of indirect calorimetry and doubly labeled water (DLW), respectively. REE was then compared to data from a previous study on aged volunteers from nursing homes who were free of an acute stressor event. Energy requirements measured by DLW were confirmed at 1.3 &times<br />REE. Energy intake covered the needs but did not prevent weight loss in these patients. TEE was not increased in hospitalized patients and was not influenced by inflammation, while the relationship between REE and inflammation was uncertain. Our results suggest that lean mass remains the major determinant of REE in hospitalized older people and that weight loss may not be explained solely by a state of hypercatabolism.

Details

Language :
English
ISSN :
20726643
Database :
OpenAIRE
Journal :
Nutrients, Nutrients, 2019, 11 (12), ⟨10.3390/nu11122946⟩, Nutrients, MDPI, 2019, 11 (12), pp.2946. ⟨10.3390/nu11122946⟩, Volume 11, Issue 12
Accession number :
edsair.pmid.dedup....584664c8b2977bc5a8dee9d2615f8b7e
Full Text :
https://doi.org/10.3390/nu11122946⟩