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Cardiac Characterization of mdx Mice Using High-Resolution Doppler Echocardiography
- Source :
- Journal of Ultrasound in Medicine, Journal of Ultrasound in Medicine, 2013, 32 (5), pp.757-761. ⟨10.7863/ultra.32.5.757⟩, Journal of Ultrasound in Medicine, American Institute of Ultrasound in Medicine, 2013, 32 (5), pp.757-761. ⟨10.7863/ultra.32.5.757⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- Duchenne muscular dystrophy is an X-linked neuromuscular disorder. The heart is traditionally involved, leading to heart failure. The mdx mouse is a natural animal model of the disease. We conducted a prospective study to analyze left ventricular (LV) function in mdx mice at different ages using high-resolution Doppler echocardiography.Echocardiography was performed with a 30-MHz cardiac probe. Wild-type and mdx mice were scanned at 10 and 12 months. We measured the interventricular septal wall thickness, posterior wall thickness, and LV diameter in systole and diastole. The LV shortening fraction, LV ejection fraction, and LV mass were then calculated.At 10 months, the shortening fractions in mdx and wild-type mice were relatively close (29% ± 5% versus 25% ± 4%). We found a significant difference in the posterior wall thickness change (40% ± 12% in mdx versus 28% ± 10% in wild-type; P = .048). The LV mass/body weight ratio was higher in mdx than wild-type mice (3.67 ± 0.25 versus 3.39 ± 0.26; P = .05). At 12 months, the LV mass was elevated in mdx mice compared to wild-type (152 ±16 versus 135 ± 3.7 mg; P = .04). The diastolic posterior wall thickness change was decreased in mdx mice at 12 months compared to wild-type (21% ± 7% versus 33% ± 4%; P = .01). The LV ejection fraction was not statistically different between mdx and wild-type mice (50% ± 6% versus 54% ± 2%).Ten-month-old mdx mice had a significantly higher posterior wall thickness than wild-type mice, but it was not significant at 12 months. In 12-month-old mdx mice, the posterior wall thickness change was significantly lower, and the LV mass was significantly higher. These findings indicate the role of LV function in the early stages of Duchenne muscular dystrophy.
- Subjects :
- musculoskeletal diseases
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
MESH: Echocardiography, Doppler
MESH: Algorithms
Sensitivity and Specificity
Mice
Ventricular Dysfunction, Left
MESH: Mice, Inbred C57BL
Image Interpretation, Computer-Assisted
MESH: Ventricular Dysfunction, Left
MESH: Muscular Dystrophy, Duchenne
Animals
MESH: Animals
MESH: Mice
MESH: Mice, Inbred mdx
Reproducibility of Results
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology
Image Enhancement
Echocardiography, Doppler
MESH: Sensitivity and Specificity
Mice, Inbred C57BL
Muscular Dystrophy, Duchenne
MESH: Reproducibility of Results
MESH: Cardiomyopathies
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
Mice, Inbred mdx
MESH: Image Enhancement
Cardiomyopathies
MESH: Image Interpretation, Computer-Assisted
Algorithms
Subjects
Details
- Language :
- English
- ISSN :
- 02784297 and 15509613
- Database :
- OpenAIRE
- Journal :
- Journal of Ultrasound in Medicine, Journal of Ultrasound in Medicine, 2013, 32 (5), pp.757-761. ⟨10.7863/ultra.32.5.757⟩, Journal of Ultrasound in Medicine, American Institute of Ultrasound in Medicine, 2013, 32 (5), pp.757-761. ⟨10.7863/ultra.32.5.757⟩
- Accession number :
- edsair.pmid.dedup....4b19ab014d72df6af7a815d480fd521a