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Role of Dectin-2 for Host Defense against Systemic Infection with Candida glabrata
- Source :
- Infection and Immunity, Infection and Immunity, American Society for Microbiology, 2014, 82 (3), pp.1064-1073. ⟨10.1128/IAI.01189-13⟩
- Publication Year :
- 2014
- Publisher :
- HAL CCSD, 2014.
-
Abstract
- International audience; Although Candida glabrata is an important pathogenic Candida species, relatively little is known about its innate immune recognition. Here, we explore the potential role of Dectin-2 for host defense against C. glabrata. Dectin-2-deficient (Dectin-2(-/-)) mice were found to be more susceptible to C. glabrata infections, showing a defective fungal clearance in kidneys but not in the liver. The increased susceptibility to infection was accompanied by lower production of T helper 1 (Th1) and Th17-derived cytokines by splenocytes of Dectin-2(-/-) mice, while macrophage-derived cytokines were less affected. These defects were associated with a moderate yet significant decrease in phagocytosis of the fungus by the Dectin-2(-/-) macrophages and neutrophils. Neutrophils of Dectin-2(-/-) mice also displayed lower production of reactive oxygen species (ROS) upon challenge with opsonized C. glabrata or C. albicans. This study suggests that Dectin-2 is important in host defense against C. glabrata and provides new insights into the host defense mechanisms against this important fungal pathogen.
- Subjects :
- Neutrophils
[SDV]Life Sciences [q-bio]
Candida glabrata
MESH: Neutrophils
[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity
Mice
Phagocytosis
MESH: Mice, Inbred C57BL
Candida albicans
Animals
Lectins, C-Type
MESH: Animals
MESH: Phagocytosis
MESH: Candida glabrata
MESH: Mice
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Host Response and Inflammation
MESH: Cytokines
Macrophages
MESH: Candida albicans
Candidiasis
MESH: Reactive Oxygen Species
MESH: Macrophages
Th1 Cells
MESH: Candidiasis
Mice, Inbred C57BL
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
MESH: Th1 Cells
Cytokines
[SDV.IMM]Life Sciences [q-bio]/Immunology
Female
Reactive Oxygen Species
MESH: Female
MESH: Lectins, C-Type
Subjects
Details
- Language :
- English
- ISSN :
- 00199567 and 10985522
- Database :
- OpenAIRE
- Journal :
- Infection and Immunity, Infection and Immunity, American Society for Microbiology, 2014, 82 (3), pp.1064-1073. ⟨10.1128/IAI.01189-13⟩
- Accession number :
- edsair.pmid.dedup....444e14b8d9b32546e7310ad9425916bd