Concentric left ventricular wall thickening in a patient with primary hypothyroidism. Response to gradual thyroxine replacement

Asymmetric septal thickening has been described in patients with overt myxedema, but descriptions of concentric left ventricular wall thickening in such patients are rare. Echocardiographic detection of thickened left ventricular and interventricular walls, without pericardial effusion or any other sign of cardiac involvement, in a patient with overt myxedema and primary hypothyroidism, is reported. Furthermore, this is the first case in which the timing and the extent of the response of such abnormalities to L-thyroxine replacement therapy have been serially evaluated.