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The early activation of CD8+ T cells is dependent on type I IFN signaling following intramuscular vaccination of adenovirus vector
- Source :
- BioMed Research International, BioMed Research International, Vol 2014 (2014)
- Publication Year :
- 2014
-
Abstract
- Few of the vaccines in current use can induce antigen- (Ag-) specific immunity in both mucosal and systemic compartments. Hence, the development of vaccines that realize both mucosal and systemic protection against various pathogens is a high priority in global health. Recently, it has been reported that intramuscular (i.m.) vaccination of an adenovirus vector (Adv) can induce Ag-specific cytotoxic T lymphocytes (CTLs) in both systemic and gut mucosal compartments. We previously revealed that type I IFN signaling is required for the induction of gut mucosal CTLs, not systemic CTLs. However, the molecular mechanism via type I IFN signaling is largely unknown. Here, we report that type I IFN signaling following i.m. Adv vaccination is required for the expression of type I IFN in the inguinal lymph nodes (iLNs), which are the draining lymph nodes of the administration site. We also showed that the type I IFN signaling is indispensable for the early activation of CTLs in iLNs. These data suggested that type I IFN signaling has an important role in the translation of systemic innate immune response into mucosal adaptive immunity by amplifying the innate immune signaling and activating CTLs in the iLN.
- Subjects :
- Mice, Knockout
Mucous Membrane
Article Subject
lcsh:R
Genetic Vectors
Vaccination
lcsh:Medicine
chemical and pharmacologic phenomena
CD8-Positive T-Lymphocytes
Lymphocyte Activation
Injections, Intramuscular
Immunity, Innate
Adenoviridae
Specific Pathogen-Free Organisms
Mice, Inbred C57BL
Mice
Interferon Type I
Animals
Immunity, Mucosal
Signal Transduction
T-Lymphocytes, Cytotoxic
Research Article
Subjects
Details
- ISSN :
- 23146141
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- BioMed research international
- Accession number :
- edsair.pmid.dedup....3a076837973fc591b0a216c8a5e29570