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Efficacy of food supplement to improve metabolic syndrome parameters in patients affected by moderate to severe psoriasis during anti-TNFα treatment
- Source :
- Scopus-Elsevier, Publons
- Publication Year :
- 2014
-
Abstract
- Psoriasis is a systemic inflammatory immune-mediated skin disease. Recently a relationship with metabolic syndrome in terms of psoriasis severity and response to therapy was observed.We performed an open-label randomized controlled study to evaluate the role of a nutraceutical containing Q10 coenzyme, Krill-oil, lipoic acid, resveratrol, Vitis vinifera seed oil, vitamin E and selenium in addition to etanercept therapy for patients affected by psoriasis and metabolic syndrome. Forty patients were enrolled and divided into two arms, one receiving only etanercept, one other receiving also the neutraceutical. After a period of 3 months (T1) a second evaluation of the considered parameters was performed.At T1 statistically significant differences were detected in HDL cholesterol and triglycerides values both comparing the two arms and in the nutraceutical arm.Our results show that the dietary addiction of the nutraceutical to the etanercept therapy in patients affected by both psoriasis and metabolic syndrome could help to restore the normal lipid profile.
- Subjects :
- Adult
Male
Ubiquinone
Severity of Illness Index
Antioxidants
Receptors, Tumor Necrosis Factor
Body Mass Index
Etanercept
Selenium
Dietary Fats, Unsaturated
Stilbenes
Animals
Humans
Psoriasis
Vitamin E
Vitis
Triglycerides
Metabolic Syndrome
Thioctic Acid
Tumor Necrosis Factor-alpha
Cholesterol, HDL
psoriasis
metabolic syndrome x
oxidative stress
Middle Aged
Treatment Outcome
Resveratrol
Immunoglobulin G
Dietary Supplements
Seeds
Female
Biomarkers
Immunosuppressive Agents
Euphausiacea
Follow-Up Studies
Subjects
Details
- ISSN :
- 03920488
- Volume :
- 148
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
- Accession number :
- edsair.pmid.dedup....397d9310e9625bfc4e282f5cff5905fb