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Microstructural models for diffusion MRI in breast cancer and surrounding stroma:an ex vivo study
- Source :
- Bailey, C, Siow, B, Panagiotaki, E, Hipwell, J H, Mertzanidou, T, Owen, J, Gazinska, P, Pinder, S, Alexander, D C & Hawkes, D J 2017, ' Microstructural models for diffusion MRI in breast cancer and surrounding stroma : an ex vivo study ', NMR in Biomedicine, vol. 30, no. 2, e3679 . https://doi.org/10.1002/nbm.3679, Nmr in Biomedicine
- Publication Year :
- 2017
-
Abstract
- The diffusion signal in breast tissue has primarily been modelled using apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM) and diffusion tensor (DT) models, which may be too simplistic to describe the underlying tissue microstructure. Formalin-fixed breast cancer samples were scanned using a wide range of gradient strengths, durations, separations and orientations. A variety of one- and two-compartment models were tested to determine which best described the data. Models with restricted diffusion components and anisotropy were selected in most cancerous regions and there were no regions in which conventional ADC or DT models were selected. Maps of ADC generally related to cellularity on histology, but maps of parameters from more complex models suggest that both overall cell volume fraction and individual cell size can contribute to the diffusion signal, affecting the specificity of ADC to the tissue microstructure. The areas of coherence in diffusion anisotropy images were small, approximately 1 mm, but the orientation corresponded to stromal orientation patterns on histology.
- Subjects :
- diffusion
Reproducibility of Results
Breast Neoplasms
restriction
anisotropy
Magnetic Resonance Imaging
Models, Biological
Sensitivity and Specificity
Diffusion Tensor Imaging
breast cancer
Connective Tissue
DTI
Image Interpretation, Computer-Assisted
Tumor Cells, Cultured
ex vivo
Humans
Computer Simulation
Female
Research Articles
Research Article
MRI
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Bailey, C, Siow, B, Panagiotaki, E, Hipwell, J H, Mertzanidou, T, Owen, J, Gazinska, P, Pinder, S, Alexander, D C & Hawkes, D J 2017, ' Microstructural models for diffusion MRI in breast cancer and surrounding stroma : an ex vivo study ', NMR in Biomedicine, vol. 30, no. 2, e3679 . https://doi.org/10.1002/nbm.3679, Nmr in Biomedicine
- Accession number :
- edsair.pmid.dedup....36861f1543efcf1a5421f75967647193