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Cre/loxP-mediated chromosome engineering of the mouse genome
- Source :
- Handb Exp Pharmacol, Handb Exp Pharmacol, Vsevolod Gurevich, 2007, pp.29-48. ⟨10.1007/978-3-540-35109-2_2⟩, ResearcherID
- Publication Year :
- 2007
- Publisher :
- HAL CCSD, 2007.
-
Abstract
- International audience; Together with numerous other genome modifications, chromosome engineering offers a very powerful tool to accelerate the functional analysis of the mammalian genome. The technology, based on the Cre/loxP system, is used more and more in the scientific community in order to generate new chromosomes carrying deletions, duplications, inversions and translocations in targeted regions of interest. In this review, we will present the basic principle of the technique either in vivo or in vitro and we will briefly describe some applications to provide highly valuable genetic tools, to decipher the mammalian genome organisation and to analyze human diseases in the mouse.
- Subjects :
- Genome
MESH: Humans
MESH: Integrases
Integrases
MESH: Chromosomes, Mammalian
Chromosomes, Mammalian
MESH: Attachment Sites, Microbiological
Mice
Mutagenesis
Attachment Sites, Microbiological
Animals
Humans
MESH: Genetic Engineering
[SDV.IMM]Life Sciences [q-bio]/Immunology
MESH: Animals
MESH: Genome
Genetic Engineering
MESH: Mice
MESH: Mutagenesis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Handb Exp Pharmacol, Handb Exp Pharmacol, Vsevolod Gurevich, 2007, pp.29-48. ⟨10.1007/978-3-540-35109-2_2⟩, ResearcherID
- Accession number :
- edsair.pmid.dedup....342a6caee17641ea00743f9221110725