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Positive selection drives accelerated evolution of mosquito salivary genes associated with blood-feeding
- Publication Year :
- 2014
- Publisher :
- WILEY-BLACKWELL, 2014.
-
Abstract
- The saliva of bloodsucking animals contains dozens to hundreds of proteins that counteract their hosts' haemostasis, inflammation and immunity. It was previously observed that salivary proteins involved in haematophagy are much more divergent in their primary sequence than those of housekeeping function, when comparisons were made between closely related organisms. While this pattern of evolution could result from relaxed selection or drift, it could alternatively be the result of positive selection driven by the intense pressure of the host immune system. We investigated the polymorphism of five different genes associated with blood-feeding in the mosquito Anopheles gambiae and obtained evidence in four genes for sites with signatures of positive selection. These results add salivary gland genes from bloodsucking arthropods to the small list of genes driven by positive selection.
- Subjects :
- Expressed Sequence Tags
anopheles gambiae
neutral theory
adaptive evolution
molecular evolution
Gene Expression Profiling
salivary glands
phylogenetic analysis
haematophagy
salivary gland
natural selection
salivary genes
Article
Evolution, Molecular
immune system
malaria vector
Anopheles
evolution
Animals
Insect Proteins
maximum-likelihood
Amino Acid Sequence
Salivary Proteins and Peptides
Selection, Genetic
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.pmid.dedup....2f5956532ccb4a4beffff1d10ac8b685