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The 763CG Polymorphism of The Secretory PLA2IIa Gene Is Associated with Endometriosis in Iranian Women

Authors :
Sahmani, Mehdi
Darabi, Masoud
Darabi, Maryam
Dabaghi, Talaat
Alizadeh, Safar Ali
Reza Najafipour
Source :
International Journal of Fertility & Sterility, International Journal of Fertility and Sterility, Vol 8, Iss 4, Pp 437-444 (2015), ResearcherID
Publication Year :
2013

Abstract

Background: Endometriosis is a chronic gynecological disease resulting from complex interactions between genetic, hormonal, environmental and oxidative stress and intrinsic inflammatory components. The aim of this study was to investigate the potential association of the 763C>G polymorphism in the secretory phospholipase A2 group IIa gene (PLA2G2A) with the risk of endometriosis in Iranian women. Materials and Methods: Ninety seven patients with endometriosis along with 107 women who were negative for endometriosis after laparoscopy and laparatomy, and served as the control group, were enrolled for this cross-sectional study. Samples were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Results: Multivariate analysis was used to examine the association between the risk of endometriosis and the 763C>G polymorphism of PLA2G2A. Genotype distributions of PLA- 2G2A were significantly different between patients and the controls (pG polymorphism of PLA2G2A plays an important role as an independent factor in the risk of endometriosis in Iranian women.

Details

ISSN :
2008076X
Volume :
8
Issue :
4
Database :
OpenAIRE
Journal :
International journal of fertilitysterility
Accession number :
edsair.pmid.dedup....2b29bc03a44d5d5cd306edb449962408