Back to Search Start Over

Longitudinal Follow-Up of Blood Telomere Length in HIV-Exposed Uninfected Children Having Received One Year of Lopinavir/Ritonavir or Lamivudine as Prophylaxis

Authors :
Monnin, Audrey
Vizeneux, Amélie
Nagot, Nicolas
Eymard-Duvernay, Sabrina
Meda, Nicolas
Singata-Madliki, Mandisa
Ndeezi, Grace
Tumwine, James K
Kankasa, Chipepo
Goga, Ameena
Tylleskär, Thorkild
Van de Perre, Philippe
Molès, Jean-Pierre
Salvy-Córdoba, Nathalie
Etablissement Français du Sang [Occitanie] (EFS Occitanie)
Université des Antilles (UA)
Pathogenesis and Control of Chronic and Emerging Infections (PCCEI)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université des Antilles (UA)-Etablissement français du don du sang [Montpellier]
Centre Muraz [Bobo-Dioulasso, Burkina Faso]
University of Fort Hare
Makerere University [Kampala, Ouganda] (MAK)
Kabale University School of medicine (KABSOM)
University of Zambia [Lusaka] (UNZA)
Centers for Disease Control and Prevention [Pretoria, South Africa] (CDC-South Africa)
Centers for Disease Control and Prevention (CDC)
University of Bergen (UiB)
Source :
Children, Volume 8, Issue 9, Children, MDPI, 2021, 8 (9), pp.796. ⟨10.3390/children8090796⟩, Children, Vol 8, Iss 796, p 796 (2021)
Publication Year :
2021
Publisher :
Multidisciplinary Digital Publishing Institute, 2021.

Abstract

Telomere shortening can be enhanced upon human immunodeficiency virus (HIV) infection and by antiretroviral (ARV) exposures. The aim of this study was to evaluate the acute and long-term effect on telomere shortening of two ARV prophylaxes, lopinavir/ritonavir (LPV/r) and lamivudine (3TC), administered to children who are HIV-exposed uninfected (CHEU) to prevent HIV acquisition through breastfeeding during the first year of life, and to investigate the relationship between telomere shortening and health outcomes at six years of age. We included 198 CHEU and measured telomere length at seven days of life, at week-50 and at six years (year-6) using quantitative polymerase chain reaction. At week-50, telomere shortening was observed among 44.3% of CHEU, irrespective of the prophylactic treatment. Furthermore, this telomere shortening was neither associated with poor growth indicators nor neuropsychological outcomes at year-6, except for motor abilities (MABC test n = 127, β = −3.61, 95%CI: −7.08, −0.14<br />p = 0.04). Safety data on telomere shortening for infant HIV prophylaxis are scarce. Its association with reduced motor abilities deserves further attention among CHEU but also HIV-infected children receiving ARV treatment.

Details

Language :
English
ISSN :
22279067
Database :
OpenAIRE
Journal :
Children
Accession number :
edsair.pmid.dedup....29a34a92f0624c8d541cb017eb504f1a
Full Text :
https://doi.org/10.3390/children8090796