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The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis
- Source :
- PLoS ONE, Vol 12, Iss 5, p e0177727 (2017), Mollison, D, Sellar, R, Bastin, M, Mollison, D, Chandran, S, Wardlaw, J & Connick, P 2017, ' The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: a systematic review and meta-analysis. ', PLoS ONE . https://doi.org/10.1371/journal.pone.0177727, PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- BackgroundModerate correlation exists between the imaging quantification of brain white matter lesions and cognitive performance in people with multiple sclerosis (MS). This may reflect the greater importance of other features, including subvisible pathology, or methodological limitations of the primary literature.ObjectivesTo summarise the cognitive clinico-radiological paradox and explore the potential methodological factors that could influence the assessment of this relationship.MethodsSystematic review and meta-analysis of primary research relating cognitive function to white matter lesion burden. ResultsFifty papers met eligibility criteria for review, and meta-analysis of overall results was possible in thirty-two (2050 participants). Aggregate correlation between cognition and T2 lesion burden was r = -0.30 (95% confidence interval: -0.34, -0.26). Wide methodological variability was seen, particularly related to key factors in the cognitive data capture and image analysis techniques. ConclusionsResolving the persistent clinico-radiological paradox will likely require simultaneous evaluation of multiple components of the complex pathology using optimum measurement techniques for both cognitive and MRI feature quantification. We recommend a consensus initiative to support common standards for image analysis in MS, enabling benchmarking while also supporting ongoing innovation.
- Subjects :
- Central Nervous System
Multiple Sclerosis
Imaging Techniques
Cognitive Neuroscience
Immunology
lcsh:Medicine
Image Analysis
Neuropsychological Tests
Research and Analysis Methods
Pathology and Laboratory Medicine
Nervous System
Diagnostic Radiology
Autoimmune Diseases
Database and Informatics Methods
Cognition
Mathematical and Statistical Techniques
Signs and Symptoms
Diagnostic Medicine
Image Processing, Computer-Assisted
Medicine and Health Sciences
Humans
Statistical Methods
Database Searching
lcsh:Science
Cognitive Impairment
Cognitive Neurology
Radiology and Imaging
lcsh:R
Brain
Biology and Life Sciences
Neurodegenerative Diseases
Magnetic Resonance Imaging
White Matter
Demyelinating Disorders
Neurology
Physical Sciences
Lesions
Cognitive Science
Clinical Immunology
lcsh:Q
Anatomy
Clinical Medicine
Publication Bias
Mathematics
Statistics (Mathematics)
Research Article
Neuroscience
Meta-Analysis
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.pmid.dedup....21c9d22569d39d6b803e4037166364cd