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Differentiation of human NK cells into NK1 and NK2 subsets
- Publication Year :
- 1998
-
Abstract
- Human NK cells cultured in the presence of IL-12 or IL-4 differentiate into cell populations with distinct patterns of cytokine secretion similar to Th1 and Th2 cells. NK cells grown in IL-12 (NK1) produce IL-10 and IFN-gamma, whereas NK cells grown in IL-4 (NK2) produce IL-5 and IL-13. Although these NK cell subsets do not differ in cytotoxic activity, NK1 cells express higher levels of cell surface CD95 (Fas) Ag than NK2 cells and are more sensitive to Ab or chemically induced apoptosis. Like Th1 cells, NK1 cells accumulate much higher levels of the IL-12Rbeta2-chain mRNA and are significantly more responsive to IL-12 than NK2 cells at the level of activation of STAT4 transcription factor. The identification of NK cell subsets that are analogous to T cell subsets suggests a new role for NK cells in innate inflammatory responses and in their effect on adaptive immunity.
- Subjects :
- Cytotoxicity, Immunologic
cytology/immunology/secretion
Cells
Cytotoxicity
T-Lymphocyte Subset
Apoptosis
Antigens
CD95
biosynthesis, Apoptosis
immunology, Cell Differentiation
immunology, Cell Division
immunology, Cells
Cultured, Coculture Techniques, Cytokines
secretion, Cytotoxicity
Immunologic, Humans, Immunologic Memory, Immunophenotyping, Interleukin-12
pharmacology, Killer Cells
Natural
cytology/immunology/metabolism, Lymphocyte Subsets
cytology/immunology/metabolism, T-Lymphocyte Subsets
cytology/immunology/secretion, Th1 Cells
cytology/metabolism, Th2 Cells
cytology/metabolism
Immunophenotyping
immunology
biosynthesi
Th2 Cells
Immunologic
T-Lymphocyte Subsets
Humans
Killer Cells
Killer Cell
fas Receptor
Coculture Technique
Th2 Cell
Cytokine
Cells, Cultured
Cultured
Apoptosi
Cell Differentiation
cytology/immunology/metabolism
Th1 Cells
Interleukin-12
Coculture Techniques
Lymphocyte Subsets
Killer Cells, Natural
secretion
Th1 Cell
Antigen
Lymphocyte Subset
Cytokines
Cell
biosynthesis
pharmacology
Immunologic Memory
Cell Division
Human
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.pmid.dedup....2011230cc6a27d6a8b8ad7764f2595d4