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The Role of BDNF in Experimental and Clinical Traumatic Brain Injury
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 3582, p 3582 (2021), International Journal of Molecular Sciences
- Publication Year :
- 2021
- Publisher :
- Uppsala universitet, Enblad: Neurokirurgi, 2021.
-
Abstract
- Traumatic brain injury is one of the leading causes of mortality and morbidity in the world with no current pharmacological treatment. The role of BDNF in neural repair and regeneration is well established and has also been the focus of TBI research. Here, we review experimental animal models assessing BDNF expression following injury as well as clinical studies in humans including the role of BDNF polymorphism in TBI. There is a large heterogeneity in experimental setups and hence the results with different regional and temporal changes in BDNF expression. Several studies have also assessed different interventions to affect the BDNF expression following injury. Clinical studies highlight the importance of BDNF polymorphism in the outcome and indicate a protective role of BDNF polymorphism following injury. Considering the possibility of affecting the BDNF pathway with available substances, we discuss future studies using transgenic mice as well as iPSC in order to understand the underlying mechanism of BDNF polymorphism in TBI and develop a possible pharmacological treatment.
- Subjects :
- neurotrophic factors
Neurologi
Brain-Derived Neurotrophic Factor
traumatic brain injury
brain
neurons
Review
Recovery of Function
neurotrophins
lcsh:Chemistry
Neuroprotective Agents
BDNF
lcsh:Biology (General)
lcsh:QD1-999
nervous system
Neurology
Brain Injuries
Brain Injuries, Traumatic
Models, Animal
Animals
Humans
neuroprotection
lcsh:QH301-705.5
neuroregeneration
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, Vol 22, Iss 3582, p 3582 (2021), International Journal of Molecular Sciences
- Accession number :
- edsair.pmid.dedup....1cb08eb88bce79de511bd6a16d2dc7ea