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Functional network segregation is associated with attenuated tau spreading in Alzheimer's disease
- Source :
- Alzheimer's and dementia 19(5), 2034-2046 (2023). doi:10.1002/alz.12867
- Publication Year :
- 2022
-
Abstract
- Lower network segregation is associated with accelerated cognitive decline in Alzheimer's disease (AD), yet it is unclear whether less segregated brain networks facilitate connectivity-mediated tau spreading.We combined resting state functional magnetic resonance imaging (fMRI) with longitudinal tau positron emission tomography (PET) in 42 betamyloid-negative controls and 81 amyloid beta positive individuals across the AD spectrum. Network segregation was determined using resting-state fMRI-assessed connectivity among 400 cortical regions belonging to seven networks.AD subjects with higher network segregation exhibited slower brain-wide tau accumulation relative to their baseline entorhinal tau PET burden (typical onset site of tau pathology). Second, by identifying patient-specific tau epicenters with highest baseline tau PET we found that stronger epicenter segregation was associated with a slower rate of tau accumulation in the rest of the brain in relation to baseline epicenter tau burden.Our results indicate that tau spreading is facilitated by a more diffusely organized connectome, suggesting that brain network topology modulates tau spreading in AD.Higher brain network segregation is associated with attenuated tau pathology accumulation in Alzheimer's disease (AD). A patient-tailored approach allows for the more precise localization of tau epicenters. The functional segregation of subject-specific tau epicenters predicts the rate of future tau accumulation.
Details
- ISSN :
- 15525279
- Database :
- OpenAIRE
- Journal :
- Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES
- Accession number :
- edsair.pmid.dedup....14a0be09df2a38b1f29d0d908e869301