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Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding
- Source :
- Chemistry (Weinheim an Der Bergstrasse, Germany)
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template‐based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia‐inducible transcription factor prolyl hydroxylase, PHD2.
- Subjects :
- Full Paper
epigenetics
Nuclear Proteins
Prolyl-Hydroxylase Inhibitors
Full Papers
Prolyl Hydroxylases
Substrate Specificity
histone demethylases
Structure-Activity Relationship
2-oxoglutarate oxygenase
medicinal chemistry
Drug Design
inhibitors
OGFOD1
Humans
barbiturate
Carrier Proteins
Medicinal Chemistry | Hot Paper
Ribosomes
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Chemistry (Weinheim an Der Bergstrasse, Germany)
- Accession number :
- edsair.pmid.dedup....1325aa488e5f1ff15a8b42f960dc3e4d