Back to Search
Start Over
Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR
- Source :
- Haematologica, Haematologica, Ferrata Storti Foundation, 2021, 106 (4), pp.1202-1206. ⟨10.3324/haematol.2019.237321⟩, Haematologica, 2021, 106 (4), pp.1202-1206. ⟨10.3324/haematol.2019.237321⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- International audience; The liver hormone hepcidin controls the main inflows of iron into plasma by binding to and inducing the degradation or the occlusion of the iron export activity of ferroportin, the only known cellular exporter of iron. When hepcidin concentrations are high, iron is trapped in enterocytes of the duodenum, hepatocytes, and macrophages. Hepcidin production by the hepatocytes is induced by a number of stimuli, most notably iron, through the BMP-SMAD signaling pathway, and inflammatory signals, through the IL-6/ STAT3 signaling axis. In addition, hepcidin has also been reported to respond to intracellular stress, namely endoplasmic reticulum (ER) stress which is involved in a number of pathophysiological states, including the inflammatory response, nutrient disorders and viral infection. A previous study has suggested that hepcidin induction by ER stress is controlled by the BMP-SMAD pathway,5 but the exact mechanism is still uncertain
- Subjects :
- MESH: Humans
MESH: Membrane Proteins / genetics
Iron
Serine Endopeptidases
Membrane Proteins
RNA-Binding Proteins
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Endoplasmic Reticulum Stress
MESH: Serine Endopeptidases / genetics
MESH: Hepcidins* / metabolism
MESH: RNA-Binding Proteins
Hepcidins
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
MESH: RNA, Messenger / genetics
[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Humans
MESH: Endoplasmic Reticulum Stress* / genetics
MESH: Membrane Proteins / metabolism
RNA, Messenger
MESH: Hepcidins* / genetics
MESH: Iron / metabolism
Letters to the Editor
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
ComputingMilieux_MISCELLANEOUS
Subjects
Details
- Language :
- English
- ISSN :
- 03906078 and 15928721
- Database :
- OpenAIRE
- Journal :
- Haematologica, Haematologica, Ferrata Storti Foundation, 2021, 106 (4), pp.1202-1206. ⟨10.3324/haematol.2019.237321⟩, Haematologica, 2021, 106 (4), pp.1202-1206. ⟨10.3324/haematol.2019.237321⟩
- Accession number :
- edsair.pmid.dedup....0f448f7c0fa5f39da70266cfaf09528b