Common genetic variants identify targets for COVID-19 and individuals at high risk of severe disease

Authors :: J E, Horowitz
J A, Kosmicki
A, Damask
D, Sharma
G H L, Roberts
A E, Justice
N, Banerjee
M V, Coignet
A, Yadav
J B, Leader
A, Marcketta
D S, Park
R, Lanche
E, Maxwell
S C, Knight
X, Bai
H, Guturu
D, Sun
A, Baltzell
F S P, Kury
J D, Backman
A R, Girshick
C, O'Dushlaine
S R, McCurdy
R, Partha
A J, Mansfield
D A, Turissini
A H, Li
M, Zhang
J, Mbatchou
K, Watanabe
L, Gurski
S E, McCarthy
H M, Kang
L, Dobbyn
E, Stahl
A, Verma
G, Sirugo
M D, Ritchie
M, Jones
S, Balasubramanian
K, Siminovitch
W J, Salerno
A R, Shuldiner
D J, Rader
T, Mirshahi
A E, Locke
J, Marchini
J D, Overton
D J, Carey
L, Habegger
M N, Cantor
K A, Rand
E L, Hong
J G, Reid
C A, Ball
A, Baras
G R, Abecasis
M A, Ferreira
Source :: medRxiv
Publication Year :: 2021
Publisher :: Cold Spring Harbor Laboratory, 2021.
Abstract: The need to identify and effectively treat COVID-19 cases at highest risk for severe disease remains critical. We identified five common genetic loci (two novel) that modulate both COVID-19 susceptibility and severity, implicating TMPRSS2, IFNAR2, CCHCR1, TCF19 and SLC6A20 as potential targets. A high genetic burden was strongly associated with increased risk of hospitalization and severe disease among COVID-19 cases, especially among individuals with few known clinical risk factors.

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