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Association between anti-thyroid peroxidase antibody and asthma in women
- Source :
- Iranian Journal of Allergy, Asthma and Immunology, Vol 11, Iss 3 (2012), Scopus-Elsevier
- Publication Year :
- 2012
-
Abstract
- About 8% of the general population suffers from autoimmune diseases, from which 78% are women. One of the most important causes of thyroid diseases is autoimmunity in origin, and it seems that people with thyroid diseases present more signs of asthma. This study was therefore designed to investigate the frequency of autoimmune thyroid diseases in women suffering from bronchial asthma. In a cross-sectional study, 100 women with asthma and 100 women as control group were tested for thyroid function and anti-thyroid peroxidase antibody (anti-TPO Ab) measurements. The asthmatic patients were selected based on having chronic cough, dyspnea, wheezing and clinical examination of the chest. The diagnosis was confirmed by pulmonary function tests. Blood tests were done by electrochemiluminescence immunoassay method. No hyperthyroid patient was found in either group. Serum TSH and Total T4 levels were not statistically different between the two groups, but serum anti-TPO Ab levels in women with asthma (74±13.6 IU/ml) was significantly higher than control group (45.24±10.56 IU/ml). After adjusting the effect of age and BMI, the relationship between asthma and anti- TPO Ab (>50 IU/ml) was statistically significant (OR=3.3, P
- Subjects :
- Adult
endocrine system
lcsh:Medicine
Iran
Thyroid Function Tests
Autoantigens
Iodide Peroxidase
Iron-Binding Proteins
Odds Ratio
Prevalence
Humans
Women
Autoantibodies
Thyroid function test
Immunoassay
Chi-Square Distribution
lcsh:R
Thyroiditis, Autoimmune
Middle Aged
Asthma
Respiratory Function Tests
Up-Regulation
Cross-Sectional Studies
Logistic Models
Case-Control Studies
Anti-thyroid peroxidase antibody
Multivariate Analysis
Female
Subjects
Details
- ISSN :
- 17351502
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Iranian journal of allergy, asthma, and immunology
- Accession number :
- edsair.pmid.dedup....01dd4ed48de792615db959474c5056b0