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Islet amyloid polypeptide in the gut and pancreas: localization, ontogeny and gut motility effects
- Source :
- Lund University
- Publication Year :
- 1997
-
Abstract
- The occurrence of islet amyloid polypeptide (IAPP) in the gut and pancreas of several species and during ontogeny of the rat, was studied using immunocytochemistry. Effects of IAPP on rat ileal smooth muscle were assessed in vitro. Islets of most, but not all, species examined, displayed IAPP in insulin cells and, in some species, also in somatostatin- and peptide YY (PYY)-containing cells. In the gut, expression of IAPP varied among species; when present, IAPP was most abundant in the proximal part and co-localized with somatostatin, PYY, gastrin/cholecystokinin, enteroglucagon or serotonin. IAPP was first demonstrated at embryonic day 12 and 16 in islet and gastrointestinal endocrine cells, respectively. IAPP relaxed gut muscle and reduced electrical field stimulation-evoked contractions, presumably by inhibiting acetylcholine release. Thus, IAPP expression in islets is consistent with an important role for IAPP in fuel metabolism; the gastrointestinal expression and motor effects of IAPP suggest that IAPP may modulate gastrointestinal function.
- Subjects :
- Amyloid
Somatostatin-Secreting Cells
Swine
Enteroendocrine Cells
Guinea Pigs
Rana temporaria
In Vitro Techniques
Bufo bufo
Rats, Sprague-Dawley
Islets of Langerhans
Mice
Dogs
Species Specificity
Ileum
Cricetinae
Animals
Humans
Peptide YY
Fluorescent Antibody Technique, Indirect
Sheep
Muscle, Smooth
Islet Amyloid Polypeptide
Rats
Cats
Female
Rabbits
Gastrointestinal Motility
Somatostatin
Chickens
Subjects
Details
- ISSN :
- 01969781
- Volume :
- 18
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Peptides
- Accession number :
- edsair.pmid.dedup....0125ce43e80ac2016fd1cf7f4462094b