[A meta-analysis on the safety of combination therapy with fenofibrate and statins]

The aim of this study was to assess the safety of fenofibrate-statin combination therapy.Medline, Cochrane Library, Web of Knowledge and CNKI were searched for 2184 randomized controlled trials. Finally, twenty-six studies with a total of 9494 participants were included in this analysis.Compared with statins group, the fenofibrate-statin group had significantly higher incidence of aminotransferase elevations (OR 1.67, 95%CI 1.22-2.30, P0.05) . The two groups had identical incidence of creatin kinase elevations (OR 0.86, 95%CI 0.62-1.20, P0.05) , muscle-associated adverse events (OR 0.98, 95%CI 0.88-1.09, P0.05) and withdrawals due to hepatotoxicity or muscle toxicity. The safety of fenofibrate + standard-dose statin regimens were similar to those in fenofibrate-statin group.Combined fenofibrate-statin treatment is generally safe and well tolerated, liver function should be monitored before and during and after therapy.