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Measurement of changes in endogenous serotonin level by positron emission tomography with [
- Source :
- Annals of nuclear medicine. 35(8)
- Publication Year :
- 2020
-
Abstract
- Positron emission tomography (PET) has been used to investigate changes in the concentration of endogenous neurotransmitters. Recently, this technique has been applied to the imaging of serotoninFirst, in the simulations, the time-activity curves at baseline and the stimulated states were generated using an extended compartment model including the competition for the receptors between the administered [In the simulations, the BP estimate of the stimulated state was smaller than that of the baseline state, and their reduction was related to the amount of change in the serotonin concentration. BP reduction was also affected by the onset of serotonin elevation. In the mouse studies, the BP of the cerebral cortex decreased in the scans with SSRI treatment.The reduction in BP estimated using the SRTM from [
- Subjects :
- Male
Mice
Serotonin
Positron-Emission Tomography
Animals
Brain
Ketanserin
Subjects
Details
- ISSN :
- 18646433
- Volume :
- 35
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Annals of nuclear medicine
- Accession number :
- edsair.pmid..........f839f7e58fd8e495b04a4e35f17059bb