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Maintaining K
- Source :
- American journal of physiology. Renal physiology. 310(7)
- Publication Year :
- 2015
-
Abstract
- A low-Na+, high-K+ diet (LNaHK) is considered a healthier alternative to the “Western” high-Na+ diet. Because the mechanism for K+ secretion involves Na+ reabsorptive exchange for secreted K+ in the distal nephron, it is not understood how K+ is eliminated with such low Na+ intake. Animals on a LNaHK diet produce an alkaline load, high urinary flows, and markedly elevated plasma ANG II and aldosterone levels to maintain their K+ balance. Recent studies have revealed a potential mechanism involving the actions of alkalosis, urinary flow, elevated ANG II, and aldosterone on two types of K+ channels, renal outer medullary K+ and large-conductance K+ channels, located in principal and intercalated cells. Here, we review these recent advances.
- Subjects :
- Animals
Humans
Potassium, Dietary
Reviews
Sodium, Dietary
Diet
Subjects
Details
- ISSN :
- 15221466
- Volume :
- 310
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- American journal of physiology. Renal physiology
- Accession number :
- edsair.pmid..........f3f5b96693481006395a72138fcf5348