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Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease
- Source :
- Journal of gastroenterology and hepatology. 33(11)
- Publication Year :
- 2017
-
Abstract
- Patients with inflammatory bowel disease (IBD) are at a high risk of low bone mineral density (BMD). Reportedly, clinical and genetic factors cause low BMD in Caucasians; however, studies in non-Caucasian populations remain scarce.Clinical risk factors for low BMD were investigated in 266 Japanese patients with IBD, and a genome-wide association analysis (GWAS) was performed using linear regression with associated clinical factors as covariates. Genotyping was performed using a population-optimized genotyping array (Japonica arrayBody mass index, age, and disease duration were independently associated with the BMD of the femoral neck (P = 1.41E - 13, 1.04E - 5, and 1.58E - 3, respectively), and body mass index and sex were associated with the BMD of the lumbar spine (P = 6.90E - 10 and 6.84E - 3, respectively). In GWAS, 118 and 42 candidate SNPs of the femoral neck and lumbar spine, respectively, were identified. Among 118, 111 candidate SNPs of the femoral neck were located within the SLC22A23 gene, which is a known IBD susceptibility gene (minimum P = 1.42E - 07). Among 42, 18 candidate SNPs of the lumbar spine were located within the MECOM gene, which is associated with osteopenia (minimum P = 5.86E - 07). Interestingly, none of the known loci showed a significant association with BMD.Although clinical risk factors for low BMD in IBD were similar to those in the general population, genetic risk factors were rather different.
- Subjects :
- Adult
Aged, 80 and over
Male
Aging
Sex Characteristics
Lumbar Vertebrae
Genotype
Femur Neck
Organic Anion Transporters
Middle Aged
Inflammatory Bowel Diseases
Polymorphism, Single Nucleotide
MDS1 and EVI1 Complex Locus Protein
Body Mass Index
Bone Diseases, Metabolic
Young Adult
Asian People
Bone Density
Risk Factors
Humans
Female
Genetic Predisposition to Disease
Aged
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 14401746
- Volume :
- 33
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of gastroenterology and hepatology
- Accession number :
- edsair.pmid..........ef6a007da253fa0db4d4902ffc0835fc