[Studies on analgesic effects and sites of oxymatrine-carbenoxolone sodium complex]

To study the analgesic effects and sites of oxymatrine-carbenoxolone sodium complex (OCSC).Adopting formalin test, warm water tail-flick test and intracerebroventricularly (icv) injection to observe the analgesic effects of OCSC in mice.Intraperitoneally injecting (ip) OCSC (75, 150 mg x kg(-1)) remarkedly inhibited the pain of mice in the formalin test and prolonged latent phases of tail-shrinking of mice, icy OCSC (1.875, 3.75, 7.5 mg x kg(-1)) significantly prolonged latent phases of tail-shrinking of mice, it had dose-dependent effect with concentration.The result indicated that OCSC has obvious analgesic effects and its mechanism may be involved in central nervous system (CNS).