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JaponiconeA induces apoptosis of bortezomib-sensitive and -resistant myeloma cells
- Source :
- Cancer biologymedicine.
- Publication Year :
- 2021
-
Abstract
- Multiple myeloma (MM) remains incurable with high rates of relapse. New therapeutic drugs are therefore urgently needed to improve the prognosis. JaponiconeA (JA), a natural product isolated fromCCK8 assays and flow cytometry were used to detect the proliferation, apoptosis, and cell cycle of MM cell lines when treated with JA.JA exhibited strong anti-tumor effects in MM. It sensitized myeloma cells to bortezomib and overcame NF-κB-induced drug resistance by inhibiting IKKβ, providing a new treatment strategy for MM patients.
Details
- ISSN :
- 20953941
- Database :
- OpenAIRE
- Journal :
- Cancer biologymedicine
- Accession number :
- edsair.pmid..........ee846ad388223af98a5ccc47c0532d74