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JaponiconeA induces apoptosis of bortezomib-sensitive and -resistant myeloma cells

Authors :
Zilu, Zhang
Chenjing, Ye
Jia, Liu
Wenbin, Xu
Chao, Wu
Qing, Yu
Xiaoguang, Xu
Xinyi, Zeng
Huizi, Jin
Yingli, Wu
Hua, Yan
Source :
Cancer biologymedicine.
Publication Year :
2021

Abstract

Multiple myeloma (MM) remains incurable with high rates of relapse. New therapeutic drugs are therefore urgently needed to improve the prognosis. JaponiconeA (JA), a natural product isolated fromCCK8 assays and flow cytometry were used to detect the proliferation, apoptosis, and cell cycle of MM cell lines when treated with JA.JA exhibited strong anti-tumor effects in MM. It sensitized myeloma cells to bortezomib and overcame NF-κB-induced drug resistance by inhibiting IKKβ, providing a new treatment strategy for MM patients.

Details

ISSN :
20953941
Database :
OpenAIRE
Journal :
Cancer biologymedicine
Accession number :
edsair.pmid..........ee846ad388223af98a5ccc47c0532d74