Back to Search
Start Over
Mettl3 regulates hypertrophic differentiation of chondrocytes through modulating Dmp1 mRNA via Ythdf1-mediated m
- Source :
- Bone. 164
- Publication Year :
- 2022
-
Abstract
- As the main cells in endochondral osteogenesis, chondrocytes have limited self-repair ability due to weak proliferation activity, low density, and dedifferentiation tendency. Here, a thorough inquiry about the effect and underlying mechanisms of methyltransferase like-3 (Mettl3) on chondrocytes was made. Functionally, it was indicated that Mettl3 promoted the proliferation and hypertrophic differentiation of chondrocytes. Mechanically, Dmp1 (dentin matrix protein 1) was proved to be the downstream direct target of Mettl3 for m
Details
- ISSN :
- 18732763
- Volume :
- 164
- Database :
- OpenAIRE
- Journal :
- Bone
- Accession number :
- edsair.pmid..........eddd621aa1764d1bd357e47d21422112