Low-Dose Near-Infrared Light-Activated Mitochondria-Targeting Photosensitizers for PDT Cancer Therapy

Authors :: Wenyu, Wu Klingler
Nadine, Giger
Lukas, Schneider
Vipin, Babu
Christiane, König
Patrick, Spielmann
Roland H, Wenger
Stefano, Ferrari
Bernhard, Spingler
Source :: International journal of molecular sciences. 23(17)
Publication Year :: 2022
Abstract: Phthalocyanines (Pcs) are promising candidates for photodynamic therapy (PDT) due to their absorption in the phototherapeutic window. However, the highly aromatic Pc core leads to undesired aggregation and decreased reactive oxygen species (ROS) production. Therefore, short PEG chain functionalized A

Subjects :: Ovarian Neoplasms
Photosensitizing Agents
Photochemotherapy
Cell Line, Tumor
Humans
Female
Triazenes
Mitochondria

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