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Human papillomavirus DNA in tissue biopsy specimens of vulvar vestibulitis patients treated with interferon

Human papillomavirus DNA in tissue biopsy specimens of vulvar vestibulitis patients treated with interferon

Authors :
S A, Umpierre
R H, Kaufman
E, Adam
K V, Woods
K, Adler-Storthz
Source :
Obstetrics and gynecology. 78(4)
Publication Year :
1991

Abstract

Thirteen women with the diagnosis of vulvar vestibulitis based on clinical symptoms, presence of vestibular tenderness on physical examination, and acetowhite changes of the vulvar vestibule were treated with intradermal injection of alpha-interferon. Biopsies of the acetowhite areas were analyzed for human papillomavirus (HPV) DNA using polymerase chain reaction amplification and dot blot hybridization. Eleven of 13 subjects harbored one of the HPV DNA types; six of these were type 16 and/or 18 and the others were unidentified. Five subjects (all HPV DNA-positive) reported resolution of symptoms with interferon therapy. Our results indicate the presence of HPV DNA in a subset of patients with vulvar vestibulitis, but its presence is not predictive of response to interferon therapy.

Details

ISSN :
00297844
Volume :
78
Issue :
4
Database :
OpenAIRE
Journal :
Obstetrics and gynecology
Accession number :
edsair.pmid..........ecc7d08b706d2261e974983aefb9283f