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BiP: Master Regulator of the Unfolded Protein Response and Crucial Factor in Flavivirus Biology
- Source :
- The Yale Journal of Biology and Medicine
- Publication Year :
- 2017
- Publisher :
- YJBM, 2017.
-
Abstract
- Flaviviruses have an intimate relationship with their host cells, utilizing host proteins during replication. Much of viral genome replication and virion assembly occurs on and within the endoplasmic reticulum (ER). As a cellular protein folding hub, the ER provides an ideal environment for flaviviruses to replicate. Flaviviruses can interact with several ER processes, including the unfolded protein response (UPR), a cellular stress mechanism responsible for managing unfolded protein accumulation and ER stress. The UPR can alter the ER environment in several ways, including increasing ER volume and quantity of available chaperones, both of which can favor viral replication. BiP, a chaperone and master regulator of the UPR, has been demonstrated to play a key role in several flavivirus infections. Here we describe what is known in regard to BiP, its implicated role with flavivirus infection, and what remains to be discovered.
- Subjects :
- GRP78
Kunjin
BiP
tick-borne encephalitis virus
viruses
Flavivirus
fungi
macromolecular substances
Review
unfolded protein response
biochemical phenomena, metabolism, and nutrition
Virus Replication
complex mixtures
dengue
West Nile
Flavivirus Infections
Animals
Humans
Japanese encephalitis
Endoplasmic Reticulum Chaperone BiP
Heat-Shock Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 15514056 and 00440086
- Volume :
- 90
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The Yale Journal of Biology and Medicine
- Accession number :
- edsair.pmid..........ea1233e24fe782126fb8a5f851cbf974