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The Impact of Beta-Catenin and glutathione-S-transferase Gene Polymorphisms on the Treatment Results and Survival of Multiple Myeloma Patients
- Source :
- Pathology Oncology Research
- Publication Year :
- 2019
- Publisher :
- Springer Netherlands, 2019.
-
Abstract
- Multiple myeloma (MM) is an incurable disease, however, novel therapeutic agents has significantly improved its prognosis. In this study we analyzed if polymorphisms in the genes of β-catenin and glutathione-S-transferase have affected the clinical course, treatment response and progression-free survival (PFS) of MM patients. Ninety-seven MM patients were involved who were administered immunomodulatory drug (Imid) or alkylating agent-based therapy. β-catenin (CTNNB1, rs4135385 A > G, rs4533622 A > C) and glutathione-S-transferase (GSTP1 105, GSTP1 114) gene polymorphisms were analyzed by Light SNiP assays. The distribution of CTNNB1 (rs4135385) AA, AG and GG genotypes were 48.4%, 47.4% and 4,1%, respectively. Patients with AA genotype were older than those who carried G allele (64.5 vs. 61.0 years of age, p
Details
- Language :
- English
- ISSN :
- 15322807 and 12194956
- Volume :
- 26
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Pathology Oncology Research
- Accession number :
- edsair.pmid..........e91a64ac8a1bbec4cb7e4af921f15a4d