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Evolution of cefiderocol resistance in
- Source :
- JAC-antimicrobial resistance. 4(1)
- Publication Year :
- 2021
-
Abstract
- Cefiderocol is a siderophore cephalosporin active against MDR Gram-negatives includingWe selected cefiderocol resistance in three clinical strains ofEach parent strain was initially susceptible to cefiderocol (MICs of 0.03125, 0.03125 and 0.125 mg/L), and one initially tested susceptible to ceftazidime/avibactam (MIC 4 mg/L). We recovered evolved isolates achieving cefiderocol resistance at MICs of 8-32 mg/L from each parental strain. Some cefiderocol resistant isolates reverted following one to four drug-free passages. Ceftazidime/avibactam MICs of passaged isolates repeatedly increased to ≥256 mg/L, and while other MICs were largely unchanged, trimethoprim/sulfamethoxazole MICs declined 4-fold in two strains. WGS revealed one evolved isolate carrying six coding mutations, while four were isogenic mutants of
Details
- ISSN :
- 26321823
- Volume :
- 4
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- JAC-antimicrobial resistance
- Accession number :
- edsair.pmid..........e82f17d27ce262f422aec1c069953a17