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Randomized study to compare valsartan ± HCTZ versus amlodipine ± HCTZ strategies to maximize blood pressure control
- Source :
- Vascular Health and Risk Management
- Publication Year :
- 2009
- Publisher :
- Dove Medical Press, 2009.
-
Abstract
- Objective: Delays in achieving blood pressure (BP) control may increase morbidity and mortality in patients with hypertension. Thus, deciding which antihypertensive agent to use and at what dosage, in addition to determining when to initiate combination therapy and which agents to combine, is important for achieving BP control. Methods: This randomized, double-blind, 14-week study was conducted to compare the efficacy and tolerability of various doses of valsartan ± hydrochlorothiazide (HCTZ) versus amlodipine ± HCTZ for maximizing BP control in 1,285 patients with uncontrolled hypertension. Patients with stage 1 hypertension and naïve to antihypertensive therapy (33.9%) started valsartan 160 mg or amlodipine 5 mg. Treatment-naïve patients with stage 2 hypertension (13.5%) or those uncontrolled on current antihypertensive monotherapy (52.6%) started valsartan 160 mg/HCTZ 12.5 mg or amlodipine 10 mg. At weeks 4, 8, and 11, patients not achieving BP control were up-titrated (maximum: valsartan 320 mg/HCTZ 25 mg, amlodipine 10 mg/HCTZ 25 mg). Results: At study end, 78.8% of patients on valsartan ± HCTZ were controlled (BP
- Subjects :
- titration
Adult
Male
hypertension
Time Factors
efficacy
Tetrazoles
Blood Pressure
combination therapy
Double-Blind Method
Humans
tolerability
Diuretics
Antihypertensive Agents
Original Research
Aged
Valine
Middle Aged
South America
Calcium Channel Blockers
hydrochlorothiazide
Europe
Treatment Outcome
Valsartan
Drug Therapy, Combination
Female
Amlodipine
Angiotensin II Type 1 Receptor Blockers
Subjects
Details
- Language :
- English
- ISSN :
- 11782048 and 11766344
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Vascular Health and Risk Management
- Accession number :
- edsair.pmid..........e64a8d2be438c42778d866e371b05785