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CD206+ resident macrophages are a candidate biomarker for renal cystic disease in preclinical models and patients with ADPKD
- Source :
- Disease modelsmechanisms.
- Publication Year :
- 2022
-
Abstract
- Although renal macrophages have been shown to contribute to cystic kidney disease in PKD animal models, it remains unclear if there is a specific macrophage subpopulation involved. Here we analyze changes in macrophage populations during renal maturation in association with cystogenesis rates in conditional Pkd2 mutant mice. We demonstrate that CD206+ resident macrophages are minimal in a normal adult kidney but accumulate in cystic areas in adult-induced Pkd2 mutants. Using Cx3cr1 null mice, we reduced macrophage number, including CD206+ macrophages, and show this significantly reduces cyst severity in adult-induced Pkd2 mutant kidneys. We also found that the number of CD206+ resident macrophage-like cells increases in kidneys and in the urine from ADPKD patients relative to the rate of renal functional decline. These data indicate a direct correlation between CD206+ resident macrophages and cyst formation and demonstrate that the CD206+ resident macrophages in urine may serve as a biomarker for renal cystic disease activity in preclinical models and ADPKD patients.
Details
- ISSN :
- 17548411
- Database :
- OpenAIRE
- Journal :
- Disease modelsmechanisms
- Accession number :
- edsair.pmid..........e51519d9aa52e146d5ab89ff523e80cb