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Aire Controls in
- Source :
- Journal of immunology (Baltimore, Md. : 1950). 201(11)
- Publication Year :
- 2018
-
Abstract
- Medullary thymic epithelial cells (mTECs), which express a wide range of tissue-restricted Ags (TRAs), contribute to the establishment of self-tolerance by eliminating autoreactive T cells and/or inducing regulatory T cells. Aire controls a diverse set of TRAs within Aire-expressing cells by employing various transcriptional pathways. As Aire has a profound effect on transcriptomes of mTECs, including TRAs not only at the single-cell but also the population level, we suspected that Aire (Aire
Details
- ISSN :
- 15506606
- Volume :
- 201
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Accession number :
- edsair.pmid..........e414b3278538ed484d2a47f03fb10add