Differential mRNA expression in the induction of DNA damage, G

Authors :: Débora Berbel Lirio, Rondina
Luan Vitor Alves, de Lima
Matheus Felipe, da Silva
Thalita Alves, Zanetti
Ingrid, Felicidade
Lilian Areal, Marques
Giuliana Castello, Coatti
Mario Sergio, Mantovani
Source :: Toxicology in vitro : an international journal published in association with BIBRA. 85
Publication Year :: 2022
Abstract: Zerumbone (ZER) is a phytochemical with antioxidant and antiproliferative properties. This study evaluated the cytoxicity of ZER combined with chemotherapeutic agents and the expression of mRNA genes related to cell cycle, cell death, xenobiotic metabolism, DNA damage, and endoplasmic reticulum (ER) stress in HepG2/C3A cells. ZER was cytotoxic (IC

Subjects :: Phytochemicals
NF-kappa B
Apoptosis
Antineoplastic Agents
Antioxidants
Xenobiotics
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP1A2
Doxorubicin
Cell Line, Tumor
Cytochrome P-450 CYP1A1
RNA, Messenger
Fluorouracil
Cisplatin
Sesquiterpenes
DNA Damage

ISSN :: 18793177
Volume :: 85
Database :: OpenAIRE
Journal :: Toxicology in vitro : an international journal published in association with BIBRA
Accession number :: edsair.pmid..........e408e7dabd716046b72ff1edaaea9c9b

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