Serum concentration fluctuation and bioavailability comparison between indomethacin sustained-release and conventional capsules during steady state

The comparison between indomethacin conventional capsule (CC) po 25 mg q 8 h or 25 mg tid and indomethacin sustained-release capsule (SRC) po 25 mg bid in human by crossover design showed that both maximal serum concentration (Cmax) and fluctuation index (FI%) of SRC were significantly lower than those of CC during steady state (P0.01). No practical differences were observed between the 2 preparations in the trough serum concentration (Cmin) and area under serum concentration-time profiles (AUC0-tau) (P0.05). The time period reaching maximal serum concentration (Tmax) of SRC was much more delayed than that of CC (P0.01). It suggested that SRC possesses a better controlled release property and could avoid a higher serum peak concentration of CC.