[Effect of Interleukin-6 Gene Deletion on Radiation-Induced Mouse Hematopoietic Injury and Relative Mechanism]

To study the effect of interleukin-6 (IL-6) gene deletion on radiation-induced hematopoietic injury in mice and relative mechanism.Before and after whole bodyIL-6 levels in serum of IL-6IL-6 plays an obvious role in regulating hematopoietic radiation injury, and IL-6 deficiency can inhibit the radiation-induced increase of endogenous G-CSF level in serum, aggravates the damage of mouse hematopoietic stem cells（HSC） and the reduction of mature blood cells in peripheral blood caused by ionizing irradiation, resulting in the shortening of the survival time and significant decrease of the survival rate of mice exposed to lethal dose radiation.白介素-6基因敲除对辐射诱导小鼠造血损伤的影响及相关机制研究.研究白介素-6（IL-6）基因敲除对辐射诱导小鼠造血损伤的影响及其相关机制.观察比较IL-6IL-6对小鼠造血辐射损伤具有明显的调控作用，IL-6基因缺失抑制辐射诱导的内源性G-CSF水平升高，加重电离辐射引起的小鼠造血干细胞损伤和外周血成熟血细胞的减少，导致致死剂量照射小鼠存活时间缩短、存活率明显下降.