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Twenty-four–Hour Measurement of Intraocular Pressure in Guinea Pigs (Cavia porcellus)

Authors :
Ansari-Mood, Maneli
Mehdi-Rajaei, Seyed
Sadjadi, Reza
Selk-Ghaffari, Masoud
Williams, David L
Publication Year :
2016
Publisher :
American Association for Laboratory Animal Science, 2016.

Abstract

The objective of this study was to measure intraocular pressure (IOP) in intact, healthy guinea pigs (15 male, 15 female) every 2 h for a 24-h period. First, IOP was measured by using rebound tonometry (RBT). After a 1-min rest period, 0.5% proparacaine ophthalmic solution, a topical anesthetic, was applied to both eyes; 4 min after anesthetic instillation, IOP was measured by using applanation tonometry (APT). The IOP was lower during the light period (0700 to 1900) than during the dark phase (2000 to 0600). The lowest IOP by both RBT and APT (3.68 and 13.37 mm Hg, respectively) occurred at 0700, whereas maximal IOP occurred at 2300 for RBT (8.12 mm Hg) but at 2100 for APT (20.62 mm Hg). No significant differences in IOP between the left and right eyes or between RBT and APT were noted. In addition, daily variations in the IOP of guinea pigs seem to be independent of sex and body weight. The results of this study may be beneficial in the diagnosis and observation of glaucoma in guinea pigs.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.pmid..........e33b28aaabf9f1aaf36db3ba7fb2e18e