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Cutaneous Angiosarcoma: Clinical and Pathology Study of 16 Cases
- Source :
- Actas dermo-sifiliograficas. 108(5)
- Publication Year :
- 2016
-
Abstract
- Primary cutaneous angiosarcoma is one of the most aggressive skin tumors and carries a very poor prognosis. Its initially indolent clinical presentation explains the frequently late diagnosis that, together with its typically multifocal pattern and poor delimitation, often makes surgery difficult. The low incidence of primary cutaneous angiosarcoma means that few large single-center series have been published. We review the clinical and pathologic characteristics of cutaneous angiosarcomas treated in our hospital, looking for prognostic factors and for possible diagnostic traits that could facilitate early diagnosis.This was a retrospective observational study including all patients diagnosed with cutaneous angiosarcoma in Instituto Valenciano de Oncología in Valencia, Spain between January 2000 and December 2015. We recorded 16 clinical parameters, including age, sex, type of angiosarcoma, site, size, and time since diagnosis, and 8 histopathologic parameters.We identified 16 patients (11 women and 5 men) with cutaneous angiosarcoma. Their mean age was 67 years (median, 71 years). The most common site was the trunk (10 cases), followed by the head and neck (5 cases). The mean size of the tumor was 10cm (median, 6.5cm). Fourteen patients underwent surgical excision. Six of the 16 patients were alive at the end of the study, after a mean follow-up period of 42.5 months.The major determinants of survival among patients with cutaneous angiosarcoma are tumor size and patient age. Other characteristics associated with a poor prognosis were infiltration of deep planes (muscle), a predominantly solid histologic pattern, and a larger number of mitoses.
- Subjects :
- Adult
Aged, 80 and over
Male
Neoplasms, Radiation-Induced
Skin Neoplasms
Radiotherapy
Hemangiosarcoma
Breast Neoplasms
Neoplasms, Second Primary
Cancer Care Facilities
Middle Aged
Prognosis
Combined Modality Therapy
Head and Neck Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Humans
Female
Radiotherapy, Adjuvant
Lymphedema
Early Detection of Cancer
Aged
Follow-Up Studies
Retrospective Studies
Subjects
Details
- ISSN :
- 15782190
- Volume :
- 108
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Actas dermo-sifiliograficas
- Accession number :
- edsair.pmid..........df5eff77b0c224ff98262f94e3e272f3