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Novel multitarget-directed ligands targeting acetylcholinesterase and σ
- Source :
- European journal of medicinal chemistry. 162
- Publication Year :
- 2018
-
Abstract
- Pleiotropic intervention may be a requirement for effective limitation of the progression of multifactorial diseases such as Alzheimer's Disease. One approach to such intervention is to design a single chemical entity capable of acting on two or more targets of interest, which are accordingly known as Multi-Target Directed Ligands (MTDLs). We recently described donecopride, the first MTDL able to simultaneously inhibit acetylcholinesterase and act as an agonist of the 5-HT
Details
- ISSN :
- 17683254
- Volume :
- 162
- Database :
- OpenAIRE
- Journal :
- European journal of medicinal chemistry
- Accession number :
- edsair.pmid..........da41c78bdbe6e3e5ba602275c9738692