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Novel multitarget-directed ligands targeting acetylcholinesterase and σ

Authors :
Julien, Lalut
Gianluca, Santoni
Delphine, Karila
Cédric, Lecoutey
Audrey, Davis
Florian, Nachon
Israel, Silman
Joel, Sussman
Martin, Weik
Tangui, Maurice
Patrick, Dallemagne
Christophe, Rochais
Source :
European journal of medicinal chemistry. 162
Publication Year :
2018

Abstract

Pleiotropic intervention may be a requirement for effective limitation of the progression of multifactorial diseases such as Alzheimer's Disease. One approach to such intervention is to design a single chemical entity capable of acting on two or more targets of interest, which are accordingly known as Multi-Target Directed Ligands (MTDLs). We recently described donecopride, the first MTDL able to simultaneously inhibit acetylcholinesterase and act as an agonist of the 5-HT

Details

ISSN :
17683254
Volume :
162
Database :
OpenAIRE
Journal :
European journal of medicinal chemistry
Accession number :
edsair.pmid..........da41c78bdbe6e3e5ba602275c9738692