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The QuantiFERON Monitor
- Source :
- Transplant infectious disease : an official journal of the Transplantation SocietyREFERENCES. 22(3)
- Publication Year :
- 2019
-
Abstract
- Following allogeneic hematopoietic stem cell transplantation (alloHCT), excessive immunosuppression can be complicated by infection, while inadequate immunosuppression can result in graft-vs-host disease (GVHD). An accurate method to assess overall immune status post HCT is lacking. The QuantiFERON MonitorWhole blood samples were prospectively collected from alloHCT recipients at conditioning followed by days 10, 30, 60, 90, 120, and 180 post-transplant and assayed by the QFM test. IFN-γ levels were correlated to time post HCT and episodes of infection and GVHD.Forty patients were enrolled in the study (68% male; median age 47 years; 58% matched related donors, 42% unrelated; 33% myeloablative). Post-stimulation IFN-γ levels rose steadily over the first 180 days post transplantation. IFN-γ levels were significantly lower in those with active infection compared to those without during the neutropenic period (P .001). The assay was predictive of CMV reactivation (VL 1000 copies/mL) post alloHCT (P = .001).This is a promising assay to demonstrate immune recovery and predict risk of infection after alloHCT and may allow tailoring of immunosuppression, antimicrobial treatment, and prophylaxis.
- Subjects :
- Adult
Male
Transplantation Conditioning
Adolescent
Hematopoietic Stem Cell Transplantation
Graft vs Host Disease
Middle Aged
Young Adult
Reinfection
Cytomegalovirus Infections
Humans
Transplantation, Homologous
Female
Prospective Studies
Reagent Kits, Diagnostic
Interferon-gamma Release Tests
Aged
Subjects
Details
- ISSN :
- 13993062
- Volume :
- 22
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Transplant infectious disease : an official journal of the Transplantation SocietyREFERENCES
- Accession number :
- edsair.pmid..........d7fe4be1b0c01224b2043df2609152bc